UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549
                                  SCHEDULE 13D
                   Under the Securities Exchange Act of 1934
                                (Amendment No. 8)*


                          AEOLUS PHARMACEUTICALS, INC.
--------------------------------------------------------------------------------
                                (Name of Issuer)

                    Common Stock, par value $0.01 per share
--------------------------------------------------------------------------------
                         (Title of Class of Securities)

                                    45325S-10-1
--------------------------------------------------------------------------------
                                 (CUSIP Number)

                                                    with a copy to:
    Mitchell D. Kaye                                Peter D. Greene, Esq.
    Xmark Asset Management, LLC                     Lowenstein Sandler PC
    301 Tresser Boulevard, Suite 1320               1251 Avenue of the Americas
    Stamford, CT 06901                              New York, NY 10020
    (203) 653-2500                                  (973) 262-6700
--------------------------------------------------------------------------------
                 (Name, Address and Telephone Number of Person
                Authorized to Receive Notices and Communications)

                                  June 6, 2006
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             (Date of Event which Requires Filing of this Statement)


If the filing person has previously  filed a statement on Schedule l3G to report
the  acquisition  that is the subject of this  Schedule  13D, and is filing this
schedule  because of Sections 240.13d-1(e), 240.13d-1(f)  or 240.13d-1(g), check
the following box. [  ]

Note:  Schedules  filed in paper format shall include a signed original and five
copies of the schedule, including all exhibits.  See Section 240.13d-7 for other
parties to whom copies are to be sent.

* The remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for  any  subsequent   amendment   containing   information  which  would  alter
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).





Cusip No.       45325S-10-1
--------------------------------------------------------------------------------
1.  Names of Reporting Persons.  I.R.S. Identification Nos. of above persons
    (entities only):
                         Xmark Asset Management, LLC
                                 13-3954392
--------------------------------------------------------------------------------
2.  Check the Appropriate Box if a Member of a Group (See Instructions):
         (a)
         (b)    X
--------------------------------------------------------------------------------
3.  SEC Use Only

--------------------------------------------------------------------------------
4.  Source of Funds (See Instructions):  WC
--------------------------------------------------------------------------------
5.  Check if Disclosure  of Legal Proceedings Is Required Pursuant to Items 2(d)
    or 2(e):               Not Applicable
--------------------------------------------------------------------------------
6.  Citizenship or Place of Organization:    New York, United States

--------------------------------------------------------------------------------
    Number of                      7. Sole Voting Power:             9,365,311*
                                     -------------------------------------------
    Shares Beneficially            8. Shared Voting Power:                    *
                                     -------------------------------------------
    Owned by
    Each Reporting                 9. Sole Dispositive Power:        8,365,311*
                                      ------------------------------------------
    Person With                    10. Shared Dispositive Power:              *
                                      ------------------------------------------
--------------------------------------------------------------------------------
11. Aggregate Amount Beneficially Owned by Each Reporting Person:   9,365,311*

--------------------------------------------------------------------------------
12. Check if  the Aggregate  Amount in  Row (11) Excludes  Certain  Shares  (See
    Instructions):         Not Applicable
--------------------------------------------------------------------------------
13. Percent of Class Represented by Amount in Row (11):   32.1%*
--------------------------------------------------------------------------------
14. Type of Reporting Person (See Instructions):  IA
--------------------------------------------------------------------------------
* This is a joint  filing by Xmark  Asset  Management,  LLC, a New York  limited
liability  company  ("XAM"),  and Xmark  Opportunity  Partners,  LLC, a Delaware
limited  liability  company  ("Opportunity  Partners"  and together with XAM the
"Reporting  Persons").  Mitchell D. Kaye,  the Chief  Executive  Officer of XAM,
exercises  sole  voting  and  investment  power with  respect to all  securities
beneficially  owned  by XAM,  and  Mr. Kaye  and  David C. Cavalier,  the  Chief
Executive  Officer and Chief  Operating  Officer,  respectively,  of Opportunity
Partners,  share  voting and  investment  power with  respect to all  securities
beneficially owned by Opportunity Partners.

As of June 6, 2006,  Xmark Fund, L.P., a Delaware  limited  partnership  ("Xmark
LP"),  held 143,354  shares of common stock,  par value $0.01 per share ("Common
Stock"), of Aeolus Pharmaceuticals, Inc., a Delaware corporation, formerly known
as Incara Pharmaceuticals Corporation (the "Company"). As of June 6, 2006, Xmark
Fund, Ltd., a Cayman Islands exempted company ("Xmark Ltd"), held 114,898 shares
of Common Stock of the Company.  XAM is the  investment  manager of Xmark LP and
Xmark Ltd and, as such,  possesses sole power to vote and direct the disposition
of all securities of the Company held by Xmark LP and Xmark Ltd.

As of June 6,  2006,  Goodnow  Capital,  L.L.C.,  a Delaware  limited  liability
company ("Goodnow"),  held 8,107,059 shares of Common Stock of the Company.  XAM
is the sole  manager of Goodnow and, as such,  possesses  sole power to vote and
direct the disposition of all securities of the Company held by Goodnow.

As of June 6, 2006, Biomedical Value Fund, L.P., a Delaware limited partnership,
and Biomedical  Offshore Value Fund,  Ltd., a Cayman  Islands  exempted  company
(together the "Biomedical  Value Funds"),  held 1,000,000 shares of Common Stock
of the Company  (the  "Biomedical  Shares")  that are subject to a Voting  Trust
Agreement,  dated April 19, 2004, by and among (i) the  Biomedical  Value Funds,
(ii) XAM and (iii) the Company.  Pursuant to the Voting Trust Agreement,  XAM is
the Voting  Trustee and, as such,  possesses  sole power to vote the  Biomedical
Shares.  While XAM may be deemed to be the  beneficial  owner of the  Biomedical
Shares  pursuant to its power to vote the Biomedical  Shares,  XAM does not own,
and expressly disclaims any pecuniary  interest in, the Biomedical  Shares.  XAM
does not  exercise  any  investment  authority  with  respect to the  Biomedical
Shares.  The Biomedical  Value Funds, in their capacity as the holders of voting
and/or investment  authority of more than 5% of the Common Stock of the Company,
separately  and/or in the aggregate,  pursuant to Reg. 13d-3 (jointly,  together
with certain  other  reporting  persons)  file  statements  separately  from the
Reporting Persons pursuant to Section 13 of the Securities Exchange Act of 1934,
as amended.

As a result of the foregoing,  for purposes of  Reg. Section  240.13d-3,  XAM is
deemed to beneficially own 9,365,311 shares of Common Stock of the Company as of
June 6,  2006,  or 32.1% of the  shares of Common  Stock of the  Company  deemed
issued and outstanding as of such date.




Cusip No.        45325S-10-1
--------------------------------------------------------------------------------
1.  Names of Reporting Persons.  I.R.S. Identification Nos. of above persons
    (entities only):
                        Xmark Opportunity Partners, LLC
                                20-2052197
--------------------------------------------------------------------------------
2.  Check the Appropriate Box if a Member of a Group (See Instructions):
         (a)
         (b)   X
--------------------------------------------------------------------------------
3.  SEC Use Only

--------------------------------------------------------------------------------
4.  Source of Funds (See Instructions):  WC
--------------------------------------------------------------------------------
5.  Check if Disclosure  of Legal Proceedings Is Required Pursuant to Items 2(d)
    or 2(e):               Not Applicable
--------------------------------------------------------------------------------
6.  Citizenship or Place of Organization:   Delaware, United States

--------------------------------------------------------------------------------
    Number of                      7. Sole Voting Power:             6,552,042*
                                     -------------------------------------------
    Shares Beneficially            8. Shared Voting Power:                    *
                                     -------------------------------------------
    Owned by
    Each Reporting                 9. Sole Dispositive Power:        6,552,042*
                                      ------------------------------------------
    Person With                    10. Shared Dispositive Power:              *
                                      ------------------------------------------
--------------------------------------------------------------------------------
11. Aggregate Amount Beneficially Owned by Each Reporting Person:   6,552,042*

--------------------------------------------------------------------------------
12. Check if  the Aggregate  Amount in  Row (11) Excludes  Certain  Shares  (See
    Instructions):         Not Applicable
--------------------------------------------------------------------------------
13. Percent of Class Represented by Amount in Row (11):   20.9%*
--------------------------------------------------------------------------------
14. Type of Reporting Person (See Instructions):  IA
--------------------------------------------------------------------------------
* This is a joint  filing by Xmark  Asset  Management,  LLC, a New York  limited
liability  company  ("XAM"),  and Xmark  Opportunity  Partners,  LLC, a Delaware
limited  liability  company  ("Opportunity  Partners"  and together with XAM the
"Reporting  Persons").  Mitchell D. Kaye,  the Chief  Executive  Officer of XAM,
exercises  sole  voting  and  investment  power with  respect to all  securities
beneficially  owned  by  XAM,  and Mr. Kaye  and  David C. Cavalier,  the  Chief
Executive  Officer and Chief  Operating  Officer,  respectively,  of Opportunity
Partners,  share  voting and  investment  power with  respect to all  securities
beneficially owned by Opportunity Partners.

As of June 6, 2006, Xmark Opportunity Fund, L.P., a Delaware limited partnership
("Opportunity  LP"), held 1,351,325  shares of common stock, par value $0.01 per
share ("Common Stock"), of Aeolus Pharmaceuticals, Inc., a Delaware corporation,
formerly known as Incara Pharmaceuticals Corporation (the "Company"). As of June
6, 2006,  Xmark  Opportunity  Fund,  Ltd.,  a Cayman  Islands  exempted  company
("Opportunity Ltd"), held 2,026,986 shares of Common Stock of the Company. As of
June 6, 2006, Xmark JV Investment  Partners,  LLC, a Delaware limited  liability
company ("JV  Partners"),  held 1,023,731 shares of Common Stock of the Company.
As of June 6, 2006,  Opportunity LP held warrants to purchase  660,000 shares of
Common Stock of the Company at an exercise price of $0.50 per share.  As of June
6, 2006,  Opportunity  Ltd held  warrants to purchase  990,000  shares of Common
Stock of the  Company at an  exercise  price of $0.50 per  share.  As of June 6,
2006, JV Partners held  warrants to purchase  500,000  shares of Common Stock of
the Company at an exercise price of $0.50 per share. All of the warrants held by
Opportunity LP,  Opportunity Ltd and JV Partners are exercisable  within 60 days
of the date of event  which  required  the  filing  of this  Amendment  No. 8 to
Schedule 13D.  Opportunity Partners is the sole member of the investment manager
of Opportunity LP and Opportunity Ltd and, as such, possesses sole power to vote
and direct the  disposition of all securities of the Company held by Opportunity
LP and Opportunity  Ltd.  Opportunity  Partners is the investment  manager of JV
Partners and, as such,  possesses sole power to vote and direct the  disposition
of all securities of the Company held by JV Partners.

As  a  result  of  the  foregoing,  for  purposes  of  Reg.  Section  240.13d-3,
Opportunity  Partners is deemed to beneficially  own 6,552,042  shares of Common
Stock of the Company as of June 6, 2006,  or 20.9% of the shares of Common Stock
of the Company deemed issued and outstanding as of such date.





THIS  AMENDMENT  NO. 8 TO  SCHEDULE  13D IS BEING  FILED  JOINTLY BY XMARK ASSET
MANAGEMENT,  LLC,  A NEW YORK  LIMITED  LIABILITY  COMPANY  ("XAM"),  AND  XMARK
OPPORTUNITY  PARTNERS,  LLC, A DELAWARE LIMITED LIABILITY COMPANY  ("OPPORTUNITY
PARTNERS",  AND TOGETHER WITH XAM, THE  "REPORTING  PERSONS"),  PURSUANT TO RULE
13d-1(k) OF THE  SECURITIES  EXCHANGE  ACT OF 1934,  AS AMENDED  (THE  "EXCHANGE
ACT").  THIS  STATEMENT  CONSTITUTES  AMENDMENT  NO. 8 TO THE  SCHEDULE  13D, AS
PREVIOUSLY  AMENDED,  FILED JOINTLY BY THE  REPORTING  PERSONS ON JULY 17, 2006.
NEITHER THE FILING OF THIS  SCHEDULE  13D, AS AMENDED,  NOR ANY OF ITS  CONTENTS
SHALL BE DEEMED TO CONSTITUTE AN ADMISSION BY THE REPORTING PERSONS OR ANY OTHER
PERSON  THAT  IT IS THE  BENEFICIAL  OWNER  OF  THE  SECURITIES  OF THE  COMPANY
BENEFICIALLY  OWNED BY ANY OTHER PERSON  (INCLUDING THE OTHER REPORTING  PERSON)
FOR PURPOSES OF SECTION 13(d) OF THE EXCHANGE ACT OR FOR ANY OTHER PURPOSE,  AND
SUCH BENEFICIAL OWNERSHIP IS EXPRESSLY DISCLAIMED.


Item 3.   Source and Amount of Funds or Other Consideration.
          -------------------------------------------------

          Item 3 of the  Schedule  13D is hereby  further  amended by adding the
following at the end thereof:

          According to the terms of the Certificate of Designations, Preferences
and  Rights  of  the  Series  A  Convertible  Preferred  Stock  (the  "Series  A
Preferred")  of the Company,  on June 6, 2006 the Company paid a dividend on the
shares of the Series A  Preferred,  which was paid in shares of Common  Stock of
the Company.  As a result of these  dividends,  Opportunity  LP received  14,322
shares of Common Stock of the Company,  Opportunity Ltd received,  21,482 shares
of Common Stock of the Company and JV Partners  received 10,850 shares of Common
Stock of the Company.

          On June 5, 2006,  the  Company  entered  into a private  placement  of
shares of Common Stock of the Company and warrants to purchase  shares of Common
Stock of the Company.  In connection with the private placement, the Company and
each of the  holders  of the  Series  A  Preferred,  including  Opportunity  LP,
Opportunity Ltd and JV Partners, entered into that certain Conversion Agreement,
dated as of June 5,  2006,  pursuant  to which  each of the  Series A  Preferred
holders  agreed to convert all of their shares of Series A Preferred into shares
of Common  Stock of the Company,  at a conversion  price of $0.50 per share upon
the closing of the private placement.  On June 6, 2006, pursuant to the terms of
the  Conversion  Agreement,  Opportunity  LP,  Opportunity  Ltd and JV  Partners
converted,  in the aggregate,  2,150,000 shares of the Series A Preferred.  As a
result of the  conversion,  Opportunity LP received  1,320,000  shares of Common
Stock of the Company,  Opportunity Ltd received 1,980,000 shares of Common Stock
of the Company and JV Partners received  1,000,000 shares of Common Stock of the
Company.

          All funds used to  purchase  the  securities  of the Company set forth
herein  on  behalf of  Opportunity  LP,  Opportunity  Ltd and JV  Partners  came
directly from the assets of  Opportunity  LP,  Opportunity  Ltd and JV Partners,
respectively.


Item 5.   Interest in Securities of the Issuer.
          ------------------------------------

          Item 5 of the Schedule 13D is hereby further  amended by deleting such
item in its entirety and substituting the following in lieu thereof:

          As of June 6, 2006,  Xmark LP held  143,354  shares of Common Stock of
the Company.  As of June 6, 2006,  Xmark Ltd held 114,898 shares of Common Stock
of the Company.  XAM is the investment manager of Xmark LP and Xmark Ltd and, as
such,  possesses sole power to vote and direct the disposition of all securities
of the Company held by Xmark LP and Xmark Ltd.

          As of June 6, 2006,  Goodnow held 8,107,059  shares of Common Stock of
the Company.  XAM is the sole manager of Goodnow  and, as such,  possesses  sole





power to vote and direct the  disposition  of all securities of the Company held
by Goodnow.

          As of June 6, 2006,  Biomedical  Value Fund,  L.P., a Delaware limited
partnership, and Biomedical Offshore Value Fund, Ltd., a Cayman Islands exempted
company (together the "Biomedical Value Funds"), held 1,000,000 shares of Common
Stock of the  Company  (the  "Biomedical  Shares")  that are subject to a Voting
Trust  Agreement,  dated April 19, 2004, by and among (i) the  Biomedical  Value
Funds,  (ii) XAM and (iii) the Company.  Pursuant to the Voting Trust Agreement,
XAM is the  Voting  Trustee  and,  as  such,  possesses  sole  power to vote the
Biomedical  Shares.  While XAM may be deemed to be the  beneficial  owner of the
Biomedical Shares pursuant to its power to vote the Biomedical  Shares, XAM does
not own, and  expressly  disclaims  any  pecuniary  interest in, the  Biomedical
Shares.  XAM does not  exercise  any  investment  authority  with respect to the
Biomedical Shares.  The Biomedical Value Funds, in their capacity as the holders
of voting and/or investment authority of more than 5% of the Common Stock of the
Company,  separately  and/or in the aggregate,  pursuant to Reg. 13d-3 (jointly,
together with certain other reporting  persons) file statements  separately from
the Reporting  Persons pursuant to Section 13 of the Securities  Exchange Act of
1934, as amended.

          As of June 6, 2006,  Opportunity  LP held  1,351,325  shares of Common
Stock of the Company,  Opportunity Ltd held 2,026,986  shares of Common Stock of
the  Company  and JV  Partners  held  1,023,731  shares of  Common  Stock of the
Company.  As of June 6, 2006,  Opportunity LP held warrants to purchase  660,000
shares of Common  Stock of the Company at an exercise  price of $0.50 per share.
As of June 6, 2006,  Opportunity Ltd held warrants to purchase 990,000 shares of
Common Stock of the Company at an exercise price of $0.50 per share.  As of June
6, 2006, JV Partners held warrants to purchase 500,000 shares of Common Stock of
the Company at an exercise price of $0.50 per share. All of the warrants held by
Opportunity LP,  Opportunity Ltd and JV Partners are exercisable  within 60 days
of the date of event  which  required  the  filing  of this  Amendment  No. 8 to
Schedule 13D.  Opportunity Partners is the sole member of the investment manager
of Opportunity LP and Opportunity Ltd and, as such, possesses sole power to vote
and direct the  disposition of all securities of the Company held by Opportunity
LP and Opportunity  Ltd.  Opportunity  Partners is the investment  manager of JV
Partners and, as such,  possesses sole power to vote and direct the  disposition
of all securities of the Company held by JV Partners.

          Based upon  information  provided by the Company,  as of June 6, 2006,
there  were  29,223,583  shares  of  Common  Stock  of the  Company  issued  and
outstanding.  As a  result  of the  foregoing,  for  purposes  of  Reg.  Section
240.13d-3, XAM is deemed to beneficially own 9,365,311 shares of Common Stock of
the  Company as of June 6, 2006,  or 32.1% of the shares of Common  Stock of the
Company deemed issued and outstanding as of such date, and Opportunity  Partners
is deemed to beneficially own 6,552,042 shares of Common Stock of the Company as
of June 6, 2006,  or 20.9% of the shares of Common  Stock of the Company  deemed
issued and outstanding as of such date.

          Except as  described in Item 3 of this  statement on Schedule  13D, as
amended,  during the 60 days prior to and including June 6, 2006,  there were no
purchases  or sales of Common Stock of the Company,  or  securities  convertible
into,  exercisable for or exchangeable  for Common Stock of the Company,  by the
Reporting  Persons,  or any person or entity controlled by the Reporting Persons
or any  person or  entity  for which the  Reporting  Persons  possess  voting or
investment control over the securities thereof. In addition, except as described
in this Schedule 13D, as amended,  to the knowledge of the Reporting Persons, no
other  securities of the Company are owned,  beneficially  or otherwise,  by any
other  person  named in Item 2 of this  Schedule  13D,  as  amended.  Except  as
described in this  Schedule  13D, as amended,  to the knowledge of the Reporting
Persons, no other person named in Item 2 has effected any transactions in shares
of Common Stock of the Company, or securities  convertible into, exercisable for
or exchangeable for shares of Common Stock of the Company, during the 60 days on
or prior to June 6, 2006.

          Neither the filing of this  Schedule  13D, as amended,  nor any of its
contents shall be deemed to constitute an admission by the Reporting  Persons or





any  other  person  that it is the  beneficial  owner of the  securities  of the
Company  beneficially  owned by any other person  (including the other Reporting
Person)  for  purposes  of Section  13(d) of the  Exchange  Act or for any other
purpose, and such beneficial ownership is expressly disclaimed.


Item 6.   Contracts, Arrangements, Understandings or Relationships with  Respect
          to Securities of the Issuer.
          ----------------------------------------------------------------------

          Item 6 of the  Schedule  13D is hereby  further  amended by adding the
following at the end thereof:

          The Company and each of each of the holders of the Series A Preferred,
including  Opportunity LP,  Opportunity  Ltd and JV Partners,  entered into that
certain Conversion  Agreement,  dated as of June 5, 2006, pursuant to which each
of the  Series A  Preferred  holders  agreed to convert  all of their  shares of
Series A Preferred  into shares of Common Stock of the Company,  at a conversion
price  of $0.50  per  share,  upon the  consummation  of the  Company's  private
placement of Common  Stock of the Company and warrants to purchase  Common Stock
of the Company.

          The  descriptions of the transactions and agreements set forth in this
Schedule 13D Amendment No. 8 are qualified in their entirety by reference to the
complete  agreements  governing such matters,  each of which are incorporated by
reference as exhibits pursuant to Item 7 hereof.  Except as otherwise  described
herein,  no contracts,  arrangements,  understandings  or similar  relationships
exist with  respect to the  securities  of the  Company  between  the  Reporting
Persons and any person or entity.


Item 7.   Material to be Filed as Exhibits.
          --------------------------------

          Item 7 of the  Schedule  13D is hereby  further  amended by adding the
following at the end thereof:

          A.   Joint filing agreement, dated  as of July 18, 2006,  by and among
Xmark Asset Management, LLC and Xmark Opportunity Partners, LLC.

          3.   Conversion Agreement dated June 5, 2006 by and among the Company,
the Company's Series A Preferred  Stockholders  named therein,  Efficacy Biotech
Master Fund Ltd. and Ronin Capital,  LLC  (incorporated  by reference to Exhibit
10.2 to the Company's  Current Report on Form 8-K, filed with the Securities and
Exchange Commission on June 6, 2006).







                                   Signature
                                   ---------

          After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information  set forth in this statement is true,  complete and
correct.


July 18, 2006                         XMARK ASSET MANAGEMENT, LLC

                                      /s/ Mitchell D. Kaye
                                      ------------------------------------------
                                      Name:  Mitchell D. Kaye
                                      Title: Chief Executive Officer


July 18, 2006                         XMARK OPPORTUNITY PARTNERS, LLC

                                      /s/ Mitchell D. Kaye
                                      ------------------------------------------
                                      Name:  Mitchell D. Kaye
                                      Title: Chief Executive Officer



Attention:  Intentional  misstatements  or omissions of fact constitute  Federal
criminal violations (See 18 U.S.C. 1001).






                                    Exhibit A
                                    ---------


                             JOINT FILING AGREEMENT
                             ----------------------


          The undersigned  agree that this Schedule 13D Amendment No. 8 relating
to the shares of common stock of  Aeolus Pharmaceuticals,  Inc. is filed jointly
on behalf of each of the undersigned pursuant to Rule 13d-1(k).


Dated:  July 18, 2006

                                            XMARK ASSET MANAGEMENT, LLC


                                            By:/s/ Mitchell D. Kaye
                                               ---------------------------------
                                               Name:  Mitchell D. Kaye
                                               Title: Chief Executive Officer


                                            XMARK OPPORTUNITY PARTNERS, LLC


                                            By:/s/ Mitchell D. Kaye
                                               ---------------------------------
                                               Name:  Mitchell D. Kaye
                                               Title: Chief Executive Officer