Ownership Submission
FORM 3
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
  CMEA VENTURES VI LP
2. Date of Event Requiring Statement (Month/Day/Year)
03/19/2013
3. Issuer Name and Ticker or Trading Symbol
TETRAPHASE PHARMACEUTICALS INC [TTPH]
(Last)
(First)
(Middle)
1 LETTERMAN DR. BLDG C, SUITE CM500
4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director __X__ 10% Owner
_____ Officer (give title below) _____ Other (specify below)
5. If Amendment, Date Original Filed(Month/Day/Year)
(Street)

SAN FRANCISCO, CA 94129
6. Individual or Joint/Group Filing(Check Applicable Line)
___ Form filed by One Reporting Person
_X_ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security
(Instr. 4)
2. Amount of Securities Beneficially Owned
(Instr. 4)
3. Ownership Form: Direct (D) or Indirect (I)
(Instr. 5)
4. Nature of Indirect Beneficial Ownership
(Instr. 5)

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly. SEC 1473 (7-02)
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number.

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 4)
2. Date Exercisable and Expiration Date
(Month/Day/Year)
3. Title and Amount of Securities Underlying Derivative Security
(Instr. 4)
4. Conversion or Exercise Price of Derivative Security 5. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 5)
6. Nature of Indirect Beneficial Ownership
(Instr. 5)
Date Exercisable Expiration Date Title Amount or Number of Shares
Series A-1 Convertible Participating Preferred   (1)   (2) Common Stock 1,693 (1) (3) $ (1) D  
Series A-1 Convertible Participating Preferred   (1)   (2) Common Stock 70,376 (1) (4) $ (1) D  
Series A-2 Convertible Participating Preferred   (1)   (2) Common Stock 2,208 (1) (3) $ (1) D  
Series A-2 Convertible Participating Preferred   (1)   (2) Common Stock 91,795 (1) (4) $ (1) D  
Series B Convertible Participating Preferred   (1)   (2) Common Stock 9,250 (1) (3) $ (1) D  
Series B Convertible Participating Preferred   (1)   (2) Common Stock 384,613 (1) (4) $ (1) D  
Series C Convertible Participating Preferred   (1)   (2) Common Stock 23,639 (1) (3) $ (1) D  
Series C Convertible Participating Preferred   (1)   (2) Common Stock 982,275 (1) (4) $ (1) D  

Reporting Owners

Reporting Owner Name / Address Relationships
Director 10% Owner Officer Other
CMEA VENTURES VI LP
1 LETTERMAN DR. BLDG C, SUITE CM500
SAN FRANCISCO, CA 94129
    X    
CMEA Ventures VI GmbH & Co. KG
1 LETTERMAN DR. BLDG C, SUITE CM500
SAN FRANCISCO, CA 94129
    X    
CMEA Ventures VI Management, L.P.
1 LETTERMAN DR. BLDG C, SUITE CM500
SAN FRANCISCO, CA 94129
    X    
Handelsman Karl D.
1 LETTERMAN DR. BLDG C, SUITE CM500
SAN FRANCISCO, CA 94129
    X    
Collier David J
1 LETTERMAN DR. BLDG C, SUITE CM500
SAN FRANCISCO, CA 94129
    X    
Watson James F
1 LETTERMAN DR. BLDG C, SUITE CM500
SAN FRANCISCO, CA 94129
    X    
Sohail Faysal A.
1 LETTERMAN DR. BLDG C, SUITE CM500
SAN FRANCISCO, CA 94129
    X    
BARUCH THOMAS R
1 LETTERMAN DR. BLDG C, SUITE CM500
SAN FRANCISCO, CA 94129
    X    

Signatures

By: CMEA Ventures VI Management, L.P., its General Partner By: /s/ Karl Handelsman, General Partner 03/19/2013
**Signature of Reporting Person Date

By: CMEA Ventures VI Management, L.P., its General Partner By: /s/ David Collier, its General Partner 03/19/2013
**Signature of Reporting Person Date

By: Faysal Sohail, its General Partner 03/19/2013
**Signature of Reporting Person Date

/s/ Karl Handelsman 03/19/2013
**Signature of Reporting Person Date

/s/ David Collier 03/19/2013
**Signature of Reporting Person Date

/s/ James Watson 03/19/2013
**Signature of Reporting Person Date

/s/ Faysal Sohail 03/19/2013
**Signature of Reporting Person Date

/s/ Thomas Baruch 03/19/2013
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 5(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) Convertible into Common Stock on a 1-for-29 basis without payment of further consideration. Each share will automatically convert into 1/29th of a share of Common Stock upon the closing of the Issuer's initial public offering.
(2) Not Applicable.
(3) Held by CMEA Ventures VI, GmbH & Co. KG. The general partner of CMEA Ventures VI, GmbH & Co. KG is CMEA Ventures VI Management, L.P. The general partners of CMEA Ventures VI Management, L.P. are Karl Handelsman, David Collier, Faysal Sohail, Thomas Baruch and James Watson. CMEA Ventures VI Management, L.P. and each of these individuals exercises shared voting and investment power over the shares held of record by CMEA Ventures VI, GmbH & Co. KG. Each of the filing persons disclaims beneficial ownership of the shares except to the extent of any pecuniary interest therein.
(4) Held by CMEA Ventures VI, L.P. The general partner of CMEA Ventures VI, L.P. is CMEA Ventures VI Management, L.P. The general partners of CMEA Ventures VI Management, L.P. are Karl Handelsman, David Collier, Faysal Sohail, Thomas Baruch and James Watson. CMEA Ventures VI Management, L.P. and each of these individuals exercises shared voting and investment power over the shares held of record by CMEA Ventures VI, L.P. Each of the filing persons disclaims beneficial ownership of the shares except to the extent of any pecuniary interest therein.

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