SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  SCHEDULE 13D
                    Under the Securities Exchange Act of 1934

                               (Amendment No. 21)*

                            ISCO International, Inc.
                                (Name of Issuer)

                          Common Stock, par value $.001
                         (Title of Class of Securities)

                                    46426P103
                                 (CUSIP Number)

                            Stephen M. Schultz, Esq.
                    Kleinberg, Kaplan, Wolff & Cohen, P.C.,
                   551 Fifth Avenue, New York, New York 10176
                               Tel: (212) 986-6000
            (Name, Address and Telephone Number of Person Authorized
                     to Receive Notices and Communications)

                                February 15, 2005
             (Date of Event which Requires Filing of this Statement)

If the filing person has previously  filed a statement on Schedule 13G to report
the  acquisition  which is the subject of this  Schedule 13D, and is filing this
schedule because of Rule 13d-1(e), 13d-1(f) or 13d-1(g), check the following box
[ ].

Note:  Schedules  filed in paper format shall include a signed original and five
copies of the  schedule,  including  all  exhibits.  See Rule 13d-7(b) for other
parties to whom copies are to be sent.

*The  remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for  any  subsequent   amendment   containing   information  which  would  alter
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).



1.       NAME OF REPORTING PERSONS
         I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)
                  Elliott Associates, L.P.

2.       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
         (a)[x]
         (b)[ ]

3.       SEC USE ONLY

4.       SOURCE OF FUNDS*
                  WC

5.       CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
         ITEMS 2(d) or 2(e) [ ]

6.       CITIZENSHIP OR PLACE OF ORGANIZATION
                  Delaware

NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH

7.       SOLE VOTING POWER
                  15,309,488

8        SHARED VOTING POWER
                  0

9.       SOLE DISPOSITIVE POWER
                  15,309,488

10.      SHARED DISPOSITIVE POWER
                  0

11.      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
                  15,309,488

12.      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11)
         EXCLUDES CERTAIN SHARES*   [ ]

13.      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
                  9.5%

14.      TYPE OF REPORTING PERSON*
                  PN

                      *SEE INSTRUCTIONS BEFORE FILLING OUT!



1.       NAME OF REPORTING PERSONS
         I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)
                  Elliott International, L.P.

2.       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
         (a)[x]
         (b)[ ]

3.       SEC USE ONLY

4.       SOURCE OF FUNDS*
                  WC

5.       CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS
         REQUIRED PURSUANT TO ITEMS 2(d) or 2(e)     [  ]

6.       CITIZENSHIP OR PLACE OF ORGANIZATION
                  Cayman Islands, British West Indies

NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH

7.       SOLE VOTING POWER
                  0

8.       SHARED VOTING POWER
                  11,076,639

9.       SOLE DISPOSITIVE POWER
                  0

10.      SHARED DISPOSITIVE POWER
                  11,076,639

11.      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH
         REPORTING PERSON
                  11,076,639

12.      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11)
         EXCLUDES CERTAIN SHARES*           [ ]

13.      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
                  6.9%

14.      TYPE OF REPORTING PERSON*
                  PN

                      *SEE INSTRUCTIONS BEFORE FILLING OUT!



1.       NAME OF REPORTING PERSONS
         I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)
                  Elliott International Capital Advisors, Inc.

2.       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
         (a)[x]
         (b)[ ]

3.       SEC USE ONLY

4.       SOURCE OF FUNDS*
                  00

5.       CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
         ITEMS 2(d) or 2(e) [  ]

6.       CITIZENSHIP OR PLACE OF ORGANIZATION
                  Delaware

NUMBER OF SHARES BENEFICIALLY OWNED BY EACH
REPORTING PERSON WITH

7.       SOLE VOTING POWER
                  0

8.       SHARED VOTING POWER
                  11,076,639

9.       SOLE DISPOSITIVE POWER
                  0

10.      SHARED DISPOSITIVE POWER
                  11,076,639

11.      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH
         REPORTING PERSON
                  11,076,639

12.      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11)
         EXCLUDES CERTAIN SHARES*           [ ]

13.      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
                  6.9%

14.      TYPE OF REPORTING PERSON*
                  CO

                      *SEE INSTRUCTIONS BEFORE FILLING OUT!



     This  statement is filed with respect to the shares of common stock,  $.001
par value  (the  "Common  Stock") of ISCO  International,  Inc.  (the  "Issuer")
beneficially owned by Elliott Associates, L.P. and its wholly-owned subsidiaries
(collectively, "Elliott"), Elliott International, L.P. ("Elliott International")
and Elliott  International  Capital Advisors,  Inc.  ("EICA")(collectively,  the
"Reporting  Persons")  as of February  23, 2005 and amends and  supplements  the
Schedule 13D dated April 7, 1999, as previously  amended (the  "Schedule  13D").
Except  as set forth  herein,  the  Schedule  13D,  as  previously  amended,  is
unmodified.

ITEM 3.         Source and Amount of Funds or Other Consideration

     The source and amount of funds used by Elliott in making its  purchases  of
the shares of Common Stock beneficially owned by it are set forth below:

SOURCE OF FUNDS                                      AMOUNT OF FUNDS
Working Capital                                      $4,692,758

     The source and amount of funds used by Elliott  International in making its
purchases of the shares of Common Stock  beneficially  owned by it are set forth
below:

SOURCE OF FUNDS                                      AMOUNT OF FUNDS
Working Capital                                      $6,597,071

ITEM 5.         Interest in Securities of the Issuer.

     (a)  Elliott  beneficially owns an aggregate of 15,309,488 shares of Common
Stock, constituting 9.5% of all of the outstanding shares of Common Stock.

     Together,  Elliott  International and EICA beneficially own an aggregate of
11,076,639  shares of Common Stock,  constituting 6.9% of all of the outstanding
shares of Common Stock.

     Elliott, Elliott International and EICA's aggregate beneficial ownership of
Common  Stock  equals  26,386,127  shares,   comprising  16.4%  of  all  of  the
outstanding shares of Common Stock.

     (b)   Elliott has the power to vote or direct the vote of, and to dispose
or direct the disposition of, the shares of Common Stock beneficially owned by
it.

     Elliott  International has the shared power with EICA to vote or direct the
vote of, and to dispose or direct the disposition of, the shares of Common Stock
owned  by  Elliott   International.   Information   regarding  each  of  Elliott
International  and  EICA is set  forth  in Item 2 of  this  Schedule  13D and is
expressly incorporated herein by reference herein.



     (c)  The following  transactions were  effected by Elliott  during the past
sixty (60) days:

                                        Approx. Price per
                    Amount of Shs.      Share (excl. of
Date     Security   Bought (Sold)       commissions)      

2/11/05  Common     (230,000)             $0.36
2/11/05  Common     (405,700)             $0.34
2/14/05  Common     (299,400)             $0.34
2/15/05  Common      (32,800)             $0.33
2/16/05  Common       (8,200)             $0.33
2/17/05  Common       (4,200)             $0.34
2/18/05  Common      (90,000)             $0.32


     The following  transactions were effected by Elliott  International  during
the past sixty (60) days:

                                        Approx. Price per
                    Amount of Shs.      Share (excl. of
Date     Security   Bought (Sold)       commissions)      

2/11/05  Common     (345,000)             $0.36
2/14/05  Common     (299,400)             $0.34
2/15/05  Common      (49,200)             $0.33
2/17/05  Common       (6,300)             $0.34
2/18/05  Common     (137,800)             $0.32


     All of the above transactions were effected on the American Stock Exchange.

     No other transactions with respect to the Common Stock that are required to
be reported and have not been previously  reported on Schedule 13D were effected
by any of the Reporting Persons during the past sixty (60) days.

     (d)  No person  other than Elliott has the right to receive or the power to
direct the receipt of  dividends  from,  or the  proceeds  from the sale of, the
shares of Common Stock beneficially owned by Elliott.

     No  person  other  than  Elliott  International  and EICA has the  right to
receive or the power to direct the receipt of  dividends  from,  or the proceeds
from the sale of,  the  shares of Common  Stock  beneficially  owned by  Elliott
International and EICA.

     (e)  Not applicable.


                                   SIGNATURES

     After reasonable  inquiry and to the best of its knowledge and belief,  the
undersigned  each certifies that the information with respect to it set forth in
this statement is true, complete and correct.

Dated:  February 25, 2005

        ELLIOTT ASSOCIATES, L.P.
        By: Elliott Capital Advisors, L.P., as General Partner
            By: Braxton Associates, Inc., as General Partner


                By:/s/ Elliott Greenberg
                   ---------------------
                       Elliot Greenberg
                       Vice President


        ELLIOTT INTERNATIONAL, L.P.
        By:  Elliott International Capital Advisors Inc.,
                as Attorney-in-Fact


                By:/s/ Elliott Greenberg
                   ---------------------
                       Elliot Greenberg
                       Vice President


        ELLIOTT INTERNATIONAL CAPITAL ADVISORS INC.


        By:/s/ Elliott Greenberg
           ---------------------
               Elliot Greenberg
               Vice President